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Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death

Feng, Shouya; Fox, Daniel; Man, Si Ming


The Gasdermin (GSDM) family consists of Gasdermin A (GSDMA), Gasdermin B (GSDMB), Gasdermin C (GSDMC), Gasdermin D (GSDMD), Gasdermin E (GSDME) and Pejvakin (PJVK). GSDMD is activated by inflammasome-associated inflammatory caspases. Cleavage of GSDMD by human or mouse caspase-1, human caspase-4, human caspase-5, and mouse caspase-11 liberates the N-terminal effector domain from the C-terminal inhibitory domain. The N-terminal domain oligomerizes in the cell membrane and forms a pore of...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Journal of Molecular Biology
DOI: 10.1016/j.jmb.2018.07.002
Access Rights: Open Access


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