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Cytosolic Recognition of Microbes and Pathogens: Inflammasomes in Action

Hayward, Jenni; Mathur, Anukriti; Ngo, Chinh; Man, Si Ming


Infection is a dynamic biological process underpinned by a complex interplay between the pathogen and the host. Microbes from all domains of life, including bacteria, viruses, fungi, and protozoan parasites, have the capacity to cause infection. Infection is sensed by the host, which often leads to activation of the inflammasome, a cytosolic macromolecular signaling platform that mediates the release of the proinflammatory cytokines interleukin-1β (IL-1β) and IL-18 and cleavage of the...[Show more]

CollectionsANU Research Publications
Date published: 2018-09-12
Type: Journal article
Source: Microbiology and Molecular Biology Reviews
DOI: 10.1128/MMBR.00015-18
Access Rights: Open Access


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