Skip navigation
Skip navigation

Detrimental Type I Interferon Signaling Dominates Protective AIM2 Inflammasome Responses during Francisella novicida Infection

Zhu, Qifan; Man, Si Ming; Karki, Rajendra; Malireddi, R.K. Subbarao; Kanneganti, Thirumala-Devi

Description

Interferons (IFNs) and inflammasomes are essential mediators of anti-microbial immunity. Type I IFN signaling drives activation of the AIM2 inflammasome in macrophages; however, the relative contribution of IFNs and inflammasome responses in host defense is less understood. We report intact AIM2 inflammasome responses in mice lacking type I IFN signaling during infection with F. novicida. Lack of type I IFN signaling conferred protection to F. novicida infection in contrast to the increased...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/159454
Source: Cell Reports
DOI: 10.1016/j.celrep.2018.02.096

Download

File Description SizeFormat Image
01_Zhu_Detrimental_Type_I_Interferon_2018.pdf1.73 MBAdobe PDFThumbnail


This item is licensed under a Creative Commons License Creative Commons

Updated:  22 January 2019/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator