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Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

Man, Si Ming; Karki, Rajendra; Kanneganti, Thirumala-Devi

Description

Cell death is a fundamental biological phenomenon that is essential for the survival and development of an organism. Emerging evidence also indicates that cell death contributes to immune defense against infectious diseases. Pyroptosis is a form of inflammatory programmed cell death pathway activated by human and mouse caspase-1, human caspase-4 and caspase-5, or mouse caspase-11. These inflammatory caspases are used by the host to control bacterial, viral, fungal, or protozoan pathogens....[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/159453
Source: Immunological Reviews
DOI: 10.1111/imr.12534

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