Skip navigation
Skip navigation

Effect of SSRI and calcium channel blockers on depression symptoms and cognitive function in elderly persons treated for hypertension: three city cohort study

Tully, Phillip J.; Peters, Ruth; Pérès, Karine; Anstey, Kaarin; Tzourio, Christophe

Description

Background: Emerging genetic, ex-vivo, and clinical trial evidence indicates that calcium channel blockers (CCB) can improve mood and cognitive function. The objective of this study was to examine the effect of selective serotonin reuptake inhibitor (SSRI) therapy augmented with CCB on depression and cognitive decline in an elderly population with hypertension. Methods: Prospective study of 296 persons treated with SSRI and antihypertensive drugs. Baseline and two year clinic assessments...[Show more]

dc.contributor.authorTully, Phillip J.
dc.contributor.authorPeters, Ruth
dc.contributor.authorPérès, Karine
dc.contributor.authorAnstey, Kaarin
dc.contributor.authorTzourio, Christophe
dc.date.accessioned2019-04-08T12:12:46Z
dc.identifier.issn1041-6102
dc.identifier.urihttp://hdl.handle.net/1885/159349
dc.description.abstractBackground: Emerging genetic, ex-vivo, and clinical trial evidence indicates that calcium channel blockers (CCB) can improve mood and cognitive function. The objective of this study was to examine the effect of selective serotonin reuptake inhibitor (SSRI) therapy augmented with CCB on depression and cognitive decline in an elderly population with hypertension. Methods: Prospective study of 296 persons treated with SSRI and antihypertensive drugs. Baseline and two year clinic assessments were used to categorize participants as users of SSRI + CCB (n = 53) or users of SSRI + other antihypertensives (n = 243). Clinic visits were performed up to four times in a ten-year period to assess depression and cognitive function. Results: The sample mean age was 75.2 ± 5.47 years and 78% of participants were female. At two year follow-up there was a significant group by time interaction showing lower Center for Epidemiological Studies-Depression (CESD) scores in the SSRI + CCB group, F(1,291) = 4.13, p = 0.043, η2 p = 0.014. Over ten-years follow-up, SSRI + CCB use was associated with improved general cognitive function (Mini-Mental State Examination: β = 0.97; 95% CI 0.14 to 1.81, p = 0.023) and immediate visual memory (Boston Visual Retention Test: β = 0.69; 95% CI 0.06 to 1.32, p = 0.033). Conclusion: The findings provide general population evidence that SSRI augmentation with CCB may improve depression and cognitive function.
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherSpringer
dc.sourceInternational Psychogeriatrics
dc.titleEffect of SSRI and calcium channel blockers on depression symptoms and cognitive function in elderly persons treated for hypertension: three city cohort study
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume30
dc.date.issued2018
local.identifier.absfor111706 - Epidemiology
local.identifier.absfor111502 - Clinical Pharmacology and Therapeutics
local.identifier.absfor111702 - Aged Health Care
local.identifier.ariespublicationa383154xPUB9613
local.type.statusPublished Version
local.contributor.affiliationTully, Phillip J. , Bordeaux Population Health Research Center
local.contributor.affiliationPeters, Ruth, College of Health and Medicine, ANU
local.contributor.affiliationPérès, Karine, Bordeaux Population Health Research Center
local.contributor.affiliationAnstey, Kaarin, College of Health and Medicine, ANU
local.contributor.affiliationTzourio, Christophe, University of Bordeaux
local.description.embargo2039-12-31
local.bibliographicCitation.issue9
local.identifier.doi10.1017/S1041610217002903
local.identifier.absseo920502 - Health Related to Ageing
local.identifier.absseo920410 - Mental Health
local.identifier.absseo920204 - Evaluation of Health Outcomes
dc.date.updated2019-03-12T07:22:01Z
local.identifier.scopusID2-s2.0-85044250113
dc.provenanceJournal: International Psychogeriatrics (ISSN: 1041-6102, ESSN: 1741-203X) RoMEO: This is a RoMEO green journal Paid OA: A paid open access option is available for this journal. Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: cross author cannot archive publisher's version/PDF
CollectionsANU Research Publications

Download

File Description SizeFormat Image
01_Tully_Effect_of_SSRI_and_calcium_2018.pdf333.31 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator