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The use of the vaccinia virus complement control protein (VCP) in the rat retina

Fernando, Nilisha; Natoli, Riccardo; Racic, Tanja; Wooff, Yvette; Provis, Jan; Valter, Krisztina


The complement system is highly implicated in both the prevalence and progression of Age-Related Macular Degeneration (AMD). Complement system inhibitors therefore have potential therapeutic value in managing excessive activation of the complement pathways in retinal degenerations. The vaccinia virus complement control protein (VCP) has been shown to be effective as a complement inhibitor in neuroinflammatory models including traumatic brain injury and spinal cord injury. We aimed to...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: PLOS ONE (Public Library of Science)
DOI: 10.1371/journal.pone.0193740
Access Rights: Open Access


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