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Fragment-Based Discovery of Inhibitors of the Bacterial DnaG-SSB Interaction

Chilingaryan, Zorik; Headey, Stephen J.; Lo, Allen T Y; Xu, Zhi-Qiang; Otting, Gottfried; Dixon, Nicholas Edward; Scanlon, Martin; Oakley, Aaron

Description

In bacteria, the DnaG primase is responsible for synthesis of short RNA primers used to initiate chain extension by replicative DNA polymerase(s) during chromosomal replication. Among the proteins with which Escherichia coli DnaG interacts is the single-stranded DNA-binding protein, SSB. The C-terminal hexapeptide motif of SSB (DDDIPF; SSB-Ct) is highly conserved and is known to engage in essential interactions with many proteins in nucleic acid metabolism, including primase. Here,...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/159343
Source: Journal of Environmental Chemical Engineering
DOI: 10.3390/antibiotics7010014

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