Total Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesterase
-
Altmetric Citations
Xu, Xingjun; Kim, Hye; Chen, Weimin; Ma, Xiang; Correy, Galen; Banwell, Martin
; Jackson, Colin
; Willis, Anthony
; Carr, Paul D
Description
The title alkaloids, 1 and 2, have been prepared using cross-coupling chemistries and together with various analogues they have been evaluated for their capacity to inhibit acetylcholinesterase. Contrary to an earlier report, it was found that biaryl 1 is not a significant inhibitor of this enzyme, and neither are any of its congeners, including alkaloid 2.
dc.contributor.author | Xu, Xingjun | |
---|---|---|
dc.contributor.author | Kim, Hye | |
dc.contributor.author | Chen, Weimin | |
dc.contributor.author | Ma, Xiang![]() | |
dc.contributor.author | Correy, Galen | |
dc.contributor.author | Banwell, Martin![]() | |
dc.contributor.author | Jackson, Colin![]() | |
dc.contributor.author | Willis, Anthony![]() | |
dc.contributor.author | Carr, Paul D | |
dc.date.accessioned | 2019-04-08T03:57:46Z | |
dc.identifier.issn | 1434-193X | |
dc.identifier.uri | http://hdl.handle.net/1885/159300 | |
dc.description.abstract | The title alkaloids, 1 and 2, have been prepared using cross-coupling chemistries and together with various analogues they have been evaluated for their capacity to inhibit acetylcholinesterase. Contrary to an earlier report, it was found that biaryl 1 is not a significant inhibitor of this enzyme, and neither are any of its congeners, including alkaloid 2. | |
dc.description.sponsorship | We thank Jinan University, the Australian Research Council, and the Institute of Advanced Studies for financial support. H. S. K. and G. J. C. are the grateful recipients of scholarships provided by the Australian Government. | |
dc.format.extent | 10 pages | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_AU | |
dc.publisher | Wiley-VCH Verlag GMBH | |
dc.rights | © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim | |
dc.source | European Journal of Organic Chemistry | |
dc.subject | AChE inhibition | |
dc.subject | Alkaloids | |
dc.subject | Biaryls | |
dc.subject | Cross coupling | |
dc.subject | Lycosinine A | |
dc.subject | Zephycandidine III | |
dc.title | Total Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesterase | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 2017 | |
dc.date.issued | 2017 | |
local.identifier.absfor | 030503 - Organic Chemical Synthesis | |
local.identifier.ariespublication | a383154xPUB7520 | |
local.publisher.url | https://www.wiley.com/en-gb | |
local.type.status | Accepted Version | |
local.contributor.affiliation | Xu, Xingjun, College of Science, The Australian National University | |
local.contributor.affiliation | Kim, Hye, College of Science, The Australian National University | |
local.contributor.affiliation | Chen, Weimin, Jinan University | |
local.contributor.affiliation | Ma, Xiang, College of Science, The Australian National University | |
local.contributor.affiliation | Correy, Galen, College of Science, The Australian National University | |
local.contributor.affiliation | Banwell, Martin, College of Science, The Australian National University | |
local.contributor.affiliation | Jackson, Colin, College of Science, The Australian National University | |
local.contributor.affiliation | Willis, Anthony, College of Science, The Australian National University | |
local.contributor.affiliation | Carr, Paul D, College of Science, The Australian National University | |
dc.relation | http://purl.org/au-research/grants/arc/DP170100926 | |
local.identifier.essn | 1099-0690 | |
local.bibliographicCitation.issue | 27 | |
local.bibliographicCitation.startpage | 4044 | |
local.bibliographicCitation.lastpage | 4053 | |
local.identifier.doi | 10.1002/ejoc.201700705 | |
local.identifier.absseo | 970103 - Expanding Knowledge in the Chemical Sciences | |
dc.date.updated | 2019-03-12T07:20:57Z | |
local.identifier.scopusID | 2-s2.0-85025650780 | |
dcterms.accessRights | Open Access | |
dc.provenance | http://sherpa.mimas.ac.uk/romeo/issn/1434-193X/ Author can archive pre-print (ie pre-refereeing). author can archive post-print (ie final draft post-refereeing) with a 12 months embargo (Sherpa/Romeo as of 8/4/2019) | |
dc.provenance | https://v2.sherpa.ac.uk/id/publication/1692..."The Accepted Version can be archived in a Non-Commercial Institutional Repository. 12 months embargo" from SHERPA/RoMEO site (as at 6/01/2021). This is the peer reviewed version of the following article: [Xu, Xingjun, et al. "Total Syntheses of the Amaryllidaceae alkaloids zephycandidine III and lycosinine A and their evaluation as inhibitors of acetylcholinesterase." European Journal of Organic Chemistry 2017.27 (2017): 4044-4053.], which has been published in final form at https://dx.doi.org/10.1002/ejoc.201700705. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | |
Collections | ANU Research Publications |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
Total Syntheses of Lycosinine A and Zephycandidine III V6 (Final) AAM.pdf | 430.67 kB | Adobe PDF | ![]() |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 19 May 2020/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator