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Total Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesterase

Xu, Xingjun; Kim, Hye; Chen, Weimin; Ma, Xiang; Correy, Galen; Banwell, Martin; Jackson, Colin; Willis, Anthony; Carr, Paul D


The title alkaloids, 1 and 2, have been prepared using cross-coupling chemistries and together with various analogues they have been evaluated for their capacity to inhibit acetylcholinesterase. Contrary to an earlier report, it was found that biaryl 1 is not a significant inhibitor of this enzyme, and neither are any of its congeners, including alkaloid 2.

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: European Journal of Organic Chemistry
DOI: 10.1002/ejoc.201700705
Access Rights: Open Access


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