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Homocysteine, grey matter and cognitive function in adults with cardiovascular disease

Ford, Andrew H.; Garrido, Griselda J.; Beer, Christopher; Lautenschlager, Nicola T.; Arnolda, Leonard; Flicker, Leon; Almeida, Osvaldo P.


BACKGROUND Elevated total plasma homocysteine (tHcy) has been associated with cognitive impairment, vascular disease and brain atrophy. METHODS We investigated 150 volunteers to determine if the association between high tHcy and cerebral grey matter volume and cognitive function is independent of cardiovascular disease. RESULTS Participants with high tHcy (≥15 µmol/L) showed a widespread relative loss of grey matter compared with people with normal tHcy, although differences between the groups...[Show more]

CollectionsANU Research Publications
Date published: 2012-03-07
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0033345


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