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Expression of the mismatch repair gene hMLH1 is enhanced in non-small cell lung cancer with EGFR mutations

Li, Mei; Zhang, Qiuping; Liu, Lina; Lu, Weipeng; Wei, Hong; Li, Rachel W.; Lu, Shen


Mismatch repair (MMR) plays a pivotal role in keeping the genome stable. MMR dysfunction can lead to carcinogenesis by gene mutation accumulation. HMSH2 and hMLH1 are two key components of MMR. High or low expression of them often mark the status of MMR function. Mutations (EGFR, KRAS, etc) are common in non-small cell lung cancer (NSCLC). However, it is not clear what role MMR plays in NSCLC gene mutations. The expression of MMR proteins hMSH2 and hMLH1, and the proliferation markers PCNA and...[Show more]

CollectionsANU Research Publications
Date published: 2013-10-24
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0078500


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