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Use of an in vivo FTA assay to assess the magnitude, functional avidity and epitope variant cross-reactivity of T Cell responses following HIV-1 recombinant poxvirus vaccination

Wijesundara, Danushka K.; Jackson, Ronald J.; Lidbury, Brett; Parish, Christopher; Quah, Benjamin J. C; Ranasinghe, Charani


Qualitative characteristics of cytotoxic CD8+ T cells (CTLs) are important in measuring the effectiveness of CTLs in controlling HIV-1 infections. Indeed, in recent studies patients who are naturally resistant to HIV-1 infections have been shown to possess CTLs that are of high functional avidity and have a high capacity to recognize HIV epitope variants, when compared to HIV-1 infection progressors. When developing efficacious vaccines, assays that can effectively measure CTL quality...[Show more]

CollectionsANU Research Publications
Date published: 2014-08-29
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0105366


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