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Differential requirement for the CD45 splicing regulator hnRNPLL for accumulation of NKT and conventional T cells

Yabas, Mehmet; Godfrey, Dale I.; Goodnow, Christopher C.; Hoyne, Gerard F.

Description

Natural killer T (NKT) cells represent an important regulatory T cell subset that develops in the thymus and contains immature (NK1.1(lo)) and mature (NK1.1(hi)) cell subsets. Here we show in mice that an inherited mutation in heterogeneous ribonucleoprotein L-like protein (hnRNPLL(thunder)), that shortens the survival of conventional T cells, has no discernible effect on NKT cell development, homeostasis or effector function. Thus, Hnrpll deficiency effectively increases the NKT∶T cell ratio...[Show more]

CollectionsANU Research Publications
Date published: 2011-11-04
Type: Journal article
URI: http://hdl.handle.net/1885/15860
Source: PLoS ONE
DOI: 10.1371/journal.pone.0026440

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