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High-Content Imaging Approaches to Quantitate Stress-Induced Changes in Nucleolar Morphology

He, Jinshu; Soo, Priscilla; Evers, Maurits; Parsons, Kate; Hein, Nadine; Hannan, Katherine; Hannan, Ross; George, Amee


The nucleolus is a dynamic subnuclear compartment that has a number of different functions, but its primary role is to coordinate the production and assembly of ribosomes. For well over 100 years, pathologists have used changes in nucleolar number and size to stage diseases such as cancer. New information about the nucleolus' broader role within the cell is leading to the development of drugs which directly target its structure as therapies for disease. Traditionally, it has been difficult to...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Assay and Drug Development Technologies
DOI: 10.1089/adt.2018.861


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