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RNA Aptamers Generated against Oligomeric Aβ40 Recognize Common Amyloid Aptatopes with Low Specificity but High Sensitivity

Rahimi, Farid; Murakami, Kazuma; Summers, Jamie L.; Chen, Chi-Hong B.; Bitan, Gal

Description

Aptamers are useful molecular recognition tools in research, diagnostics, and therapy. Despite promising results in other fields, aptamer use has remained scarce in amyloid research, including Alzheimer's disease (AD). AD is a progressive neurodegenerative disease believed to be caused by neurotoxic amyloid beta-protein (Abeta) oligomers. Abeta oligomers therefore are an attractive target for development of diagnostic and therapeutic reagents. We used covalently-stabilized oligomers of the...[Show more]

CollectionsANU Research Publications
Date published: 2009-11
Type: Journal article
URI: http://hdl.handle.net/1885/15771
Source: PLoS ONE
DOI: 10.1371/journal.pone.0007694

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