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Locating the Route of Entry and Binding Sites of Benzocaine and Phenytoin in a Bacterial Voltage Gated Sodium Channel

Martin, Lewis J.; Corry, Ben

Description

Sodium channel blockers are used to control electrical excitability in cells as a treatment for epileptic seizures and cardiac arrhythmia, and to provide short term control of pain. Development of the next generation of drugs that can selectively target one of the nine types of voltage-gated sodium channel expressed in the body requires a much better understanding of how current channel blockers work. Here we make use of the recently determined crystal structure of the bacterial voltage gated...[Show more]

CollectionsANU Research Publications
Date published: 2014-07-03
Type: Journal article
URI: http://hdl.handle.net/1885/15761
Source: PLoS Computational Biology
DOI: 10.1371/journal.pcbi.1003688

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