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Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides

Grönke, Sebastian; Clarke, David-Francis; Broughton, Susan; Andrews, T. Daniel; Partridge, Linda


Multicellular animals match costly activities, such as growth and reproduction, to the environment through nutrient-sensing pathways. The insulin/IGF signaling (IIS) pathway plays key roles in growth, metabolism, stress resistance, reproduction, and longevity in diverse organisms including mammals. Invertebrate genomes often contain multiple genes encoding insulin-like ligands, including seven Drosophila insulin-like peptides (DILPs). We investigated the evolution, diversification, redundancy,...[Show more]

CollectionsANU Research Publications
Date published: 2010-02-26
Type: Journal article
Source: PLoS Genetics
DOI: 10.1371/journal.pgen.1000857


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