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The kinematics of cytotoxic lymphocytes influence their ability to kill target cells

Bhat, Purnima; Leggatt, Graham; Matthaei, Klaus I.; Frazer, Ian H.


Cytotoxic lymphocytes (CTL) have been reported to show a range of motility patterns from rapid long-range tracking to complete arrest, but how and whether these kinematics affect their ability to kill target cells is not known. Many in vitro killing assays utilize cell lines and tumour-derived cells as targets, which may be of limited relevance to the kinetics of CTL-mediated killing of somatic cells. Here, live-cell microscopy is used to examine the interactions of CTL and primary murine skin...[Show more]

CollectionsANU Research Publications
Date published: 2014-05-06
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0095248


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