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Fabrication of psoralen-loaded lipid-polymer hybrid nanoparticles and their reversal effect on drug resistance of cancer cells

Yuan, Yueling; Chiba, Peter; Cai, Tiange; Callaghan, Richard; Bai, Li; Cole, Susan P.C.; Cai, Yu


In the present study, a lipid-polymer hybrid drug carrier system was developed to encapsulate psoralen (PSO), a multidrug resistance reversal agent and traditional Chinese medicine. Emphasis was focused the parameters that influence physicochemical characteristics, and then the drug release profile, stability, cytotoxicity and drug resistance reversal effect of the lipid-polymer hybrid nanoparticles (LPNs) were investigated. It was found that various formulation parameters affected NP size,...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Oncology Reports
DOI: 10.3892/or.2018.6492
Access Rights: Open Access


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