Role of host haem biosynthetic enzymes in the Plasmodium falciparum erythrocyte-stage
Plasmodium falciparum is a parasite that causes severe type of malaria, including cerebral malaria. Its growth and survival in erythrocytes relies on haem, an essential metabolic cofactor participating in various redox reactions of nearly all eukaryotic organisms. Research has therefore focused on interfering with the acquisition of haem by studying three ways parasite can access haem. The first way is through its own de novo haem synthetic pathway (HSP), in which succinyl-CoA and glycine are...[Show more]
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