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ADGRL3 (LPHN3) variants predict substance use disorder

Arcos-Burgos, Mauricio; Vélez, Jorge I; Martinez, Ariel F; Ribasés, Marta; Ramos-Quiroga, Josep A; Sánchez-Mora, Cristina; Richarte, Vanesa; Roncero, Carlos; Cormand, Bru; Fernández-Castillo, Noelia; Casas, Miguel; Lopera, Francisco; Pineda, David A; Palacio, Juan D; Acosta-López, Johan E; Cervantes-Henriquez, Martha L; Sánchez-Rojas, Manuel G; Puentes-Rozo, Pedro J; Molina, Brooke S G; Boden, Margaret T; Wallis, Deeann; Lidbury, Brett; Newman, Saul; Easteal, Simon; Swanson, James; Patel, Hardip; Volkow, Nora; Acosta, Maria T; Castellanos, Francisco X; de Leon, Jose; Mastronardi, Claudio A; Muenke, Maximilian


Genetic factors are strongly implicated in the susceptibility to develop externalizing syndromes such as attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder, conduct disorder, and substance use disorder (SUD). Variants in the ADGRL3 (LPHN3) gene predispose to ADHD and predict ADHD severity, disruptive behaviors comorbidity, long-term outcome, and response to treatment. In this study, we investigated whether variants within ADGRL3 are associated with SUD, a disorder...[Show more]

CollectionsANU Research Publications
Date published: 2019-01-29
Type: Journal article
Source: Translational psychiatry
DOI: 10.1038/s41398-019-0396-7
Access Rights: Open Access


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