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Identification of Novel Inhibitors of the Amino Acid Transporter B0AT1 (SLC6A19), a Potential Target to Induce Protein Restriction and to Treat Type 2 Diabetes

Cheng, Qi

Description

Apical broad-spectrum neutral (0) amino acid transporter B0AT1 (encoded by the SLC6A19 gene) is mainly expressed in small intestine and kidney, mediating the transport of all neutral amino acids in a Na+-dependent manner. Its ancillary proteins, carboxypeptidase angiotensin-converting enzyme 2 (ACE2) and the homolog collectrin (TMEM27, transmembrane protein 27), are critical for the surface expression and catalytic transport function in small intestine and...[Show more]

CollectionsOpen Access Theses
Date published: 2019
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/157007
DOI: 10.25911/5c7f93df4f4bd

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