Identification of Novel Inhibitors of the Amino Acid Transporter B0AT1 (SLC6A19), a Potential Target to Induce Protein Restriction and to Treat Type 2 Diabetes
Apical broad-spectrum neutral (0) amino acid transporter B0AT1 (encoded by the SLC6A19 gene) is mainly expressed in small intestine and kidney, mediating the transport of all neutral amino acids in a Na+-dependent manner. Its ancillary proteins, carboxypeptidase angiotensin-converting enzyme 2 (ACE2) and the homolog collectrin (TMEM27, transmembrane protein 27), are critical for the surface expression and catalytic transport function in small intestine and...[Show more]
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