Extracellular Interactions of Alpha-Synuclein in Multiple System Atrophy
Multiple system atrophy, characterized by atypical Parkinsonism, results from central nervous system (CNS) cell loss and dysfunction linked to aggregates of the normally pre-synaptic α-synuclein protein. Mostly cytoplasmic pathological α-synuclein inclusion bodies occur predominantly in oligodendrocytes in affected brain regions and there is evidence that α-synuclein released by neurons is taken up preferentially by oligodendrocytes. However, extracellular α-synuclein has also been shown to...[Show more]
|Collections||ANU Research Publications|
|Source:||International journal of molecular sciences|
|Access Rights:||Open access|
|01_Valdinocci_Extracellular_Interactions_of_2018.pdf||2.02 MB||Adobe PDF|
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