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Do Maternal Vitamin D Levels Influence Vitamin D Levels in Preterm Neonates?

Panda, M; McIntosh, J; Chaudhari, Tejasvi; Kent, A L

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Objective To determine the prevalence of Vitamin D (VitD) deficiency/insufficiency in mothers of preterm neonates less than or equal to 32 weeks of gestation and determine if the current level of VitD supplementation used for preterm neonates is appropriate. Design Prospective study from 10th May 2015 to 1st November 2016. Setting Neonatal Intensive Care Unit at the Canberra Hospital. Patients Mothers and their preterm neonates born less than or equal to 32 weeks gestation. Interventions...[Show more]

dc.contributor.authorPanda, M
dc.contributor.authorMcIntosh, J
dc.contributor.authorChaudhari, Tejasvi
dc.contributor.authorKent, A L
dc.date.accessioned2019-03-05T03:13:58Z
dc.date.available2019-03-05T03:13:58Z
dc.identifier.issn1687-9740
dc.identifier.urihttp://hdl.handle.net/1885/156983
dc.description.abstractObjective To determine the prevalence of Vitamin D (VitD) deficiency/insufficiency in mothers of preterm neonates less than or equal to 32 weeks of gestation and determine if the current level of VitD supplementation used for preterm neonates is appropriate. Design Prospective study from 10th May 2015 to 1st November 2016. Setting Neonatal Intensive Care Unit at the Canberra Hospital. Patients Mothers and their preterm neonates born less than or equal to 32 weeks gestation. Interventions Maternal VitD levels were obtained within 3-4 days following delivery. Neonatal VitD levels were obtained in the first 3-4 days of life, at 3-4 weeks of age, and at 6-8 weeks of age. Demographic data and data on VitD intake from parenteral nutrition, enteral feeds, and vitamin supplementation agents were collected. Results 70 neonates were enrolled into the study. Median gestation was 29 (27-30) weeks and median birth weight 1197 (971.2-1512.5) grams. Median maternal VitD level was 54.5 (36-70.7) nmol/L, median neonatal Vit D level at birth was 57 (42-70) nmol/L. Median Vit D level at 3 weeks and 6 weeks were 63.5 nmol/L (53-80.2) nmol/L and 103 (71.5-144) nmol/L respectively. 22/55 (40%) mothers were VitD deficient/insufficient. 25/70 (36%) neonates were VitD deficient/insufficient at birth. Of those neonates who were VitD deficient/insufficient at birth 5/25(10%) were deficient/insufficient at 6 weeks. The median intake of VitD at 6 weeks was 826.5 (577.5-939.5) IU/day. Conclusions VitD deficiency/insufficiency in mothers of preterm neonates and in preterm neonates at birth is common. Routine screening of maternal VitD and their preterm neonates along with individualized supplementation regimens in mothers and preterm infants may optimize VitD status and reduce risk of ongoing VitD deficiency/insufficiency.
dc.format7 pages
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherHindawi Publishing Corporation
dc.rights© 2019 M. Panda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.sourceInternational journal of pediatrics
dc.subjectVitamin D (VitD)
dc.subjectdeficiency
dc.subjectinsufficiency
dc.subjectpreterm
dc.subjectneonates
dc.subjectless than or equal to 32 weeks
dc.subjectsupplementation
dc.titleDo Maternal Vitamin D Levels Influence Vitamin D Levels in Preterm Neonates?
dc.typeJournal article
local.identifier.citationvolume2019
dcterms.dateAccepted2018-11-25
dc.date.issued2019-01-01
local.publisher.urlhttps://www.hindawi.com/
local.type.statusPublished Version
local.contributor.affiliationChaudhari, Tejasvi, ANU Medical School, CHM ANU Medical School, The Australian National University
local.contributor.affiliationKent, A. L., ANU Medical School, CHM ANU Medical School, The Australian National University
local.identifier.essn1687-9759
local.bibliographicCitation.startpage8613414
local.identifier.doi10.1155/2019/8613414
dcterms.accessRightsOpen Access
dc.provenancehttp://www.sherpa.ac.uk/romeo/issn/1687-9740/Author can archive publisher's version/PDF on any website (Sherpa/Romeo as of 5/3/2019).
CollectionsANU Research Publications

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