Regulatory roles of IL-10-producing T follicular cells
Mucosal lymphoid tissues like human tonsils are colonized by bacteria and exposed to ingested and inhaled antigens, requiring tight regulation of immune responses. Antibody responses are regulated by follicular helper T cells (TFH) and Foxp3+ follicular regulatory T cells (TFR). Here we describe a subset of human tonsillar follicular T cells (TF) identified by expression of TFH cell markers and CD25 that are the main source of T cell-derived IL-10 in the follicle. Despite lack of FOXP3...[Show more]
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