Heparanase and autoimmune diabetes
Heparanase (Hpse) is the only known mammalian endo-β-d-glucuronidase that degrades the glycosaminoglycan heparan sulfate (HS), found attached to the core proteins of heparan sulfate proteoglycans (HSPGs). Hpse plays a homeostatic role in regulating the turnover of cell-associated HS and also degrades extracellular HS in basement membranes (BMs) and the extracellular matrix (ECM), where HSPGs function as a barrier to cell migration. Secreted Hpse is harnessed by leukocytes to facilitate their...[Show more]
|Collections||ANU Research Publications|
|Source:||Frontiers in Immunology|
|01_Simeonovic_Heparanase_and_autoimmune_2013.pdf||902.02 kB||Adobe PDF|
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