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Heparanase and autoimmune diabetes

Simeonovic, Charmaine; Ziolkowski, Andrew F; Wu, Zuopeng; Choong, Fui Jiun; Freeman, Craig; Parish, Christopher


Heparanase (Hpse) is the only known mammalian endo-β-d-glucuronidase that degrades the glycosaminoglycan heparan sulfate (HS), found attached to the core proteins of heparan sulfate proteoglycans (HSPGs). Hpse plays a homeostatic role in regulating the turnover of cell-associated HS and also degrades extracellular HS in basement membranes (BMs) and the extracellular matrix (ECM), where HSPGs function as a barrier to cell migration. Secreted Hpse is harnessed by leukocytes to facilitate their...[Show more]

CollectionsANU Research Publications
Date published: 2013-12-26
Type: Journal article
Source: Frontiers in Immunology
DOI: 10.3389/fimmu.2013.00471


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