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Gamma-irradiated influenza A virus provides adjuvant activity to a co-administered poorly immunogenic SFV vaccine in mice

Babb, Rachelle; Chan, Jennifer; Khairat, Jasmine E.; Furuya, Yoichi; Alsharifi, Mohammed


Many currently available inactivated vaccines require "adjuvants" to maximize the protective immune responses generated against the antigens of interest. Recent studies in mice with gamma-irradiated influenza A virus (γ-FLU) have shown its superior efficacy compared to other forms of inactivated FLU vaccines and its ability to induce both potent interferon type-I (IFN-I) responses and the IFN-I-associated partial lymphocyte activation. Commonly, IFN-I responses induced by adjuvants, combined in...[Show more]

CollectionsANU Research Publications
Date published: 2014-06-10
Type: Journal article
Source: Frontiers in Immunology
DOI: 10.3389/fimmu.2014.00267


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