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Insights into the biogenesis and potential functions of exonic circular RNA

Ragan, Chikako; Goodall, Gregory J.; Shirokikh, Nikolay; Preiss, Thomas

Description

Circular RNAs (circRNAs) exhibit unique properties due to their covalently closed nature. Models of circRNAs synthesis and function are emerging but much remains undefined about this surprisingly prevalent class of RNA. Here, we identified exonic circRNAs from human and mouse RNA-sequencing datasets, documenting multiple new examples. Addressing function, we found that many circRNAs co-sediment with ribosomes, indicative of their translation potential. By contrast, circRNAs with potential...[Show more]

CollectionsANU Research Publications
Date published: 2019-02-14
Type: Journal article
URI: http://hdl.handle.net/1885/156516
Source: Scientific Reports
DOI: 10.1038/s41598-018-37037-0
Access Rights: Open Access

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