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The tyrosine transporter of Toxoplasma gondii is a member of the newly defined apicomplexan amino acid transporter (ApiAT) family

Parker, Kathryn; Fairweather, Stephen; Rajendran, Esther; Blume, Martin; McConville, Malcolm J.; Broer, Stefan; Kirk, Kiaran; van Dooren, Giel

Description

Apicomplexan parasites are auxotrophic for a range of amino acids which must be salvaged from their host cells, either through direct uptake or degradation of host proteins. Here, we describe a family of plasma membrane-localized amino acid transporters, termed the Apicomplexan Amino acid Transporters (ApiATs), that are ubiquitous in apicomplexan parasites. Functional characterization of the ApiATs of Toxoplasma gondii indicate that several of these transporters are important for intracellular...[Show more]

CollectionsANU Research Publications
Date published: 2019-02-11
Type: Journal article
URI: http://hdl.handle.net/1885/156511
Source: PLOS Pathogens
DOI: 10.1371/journal.ppat.1007577
Access Rights: Open Access

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