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An experimental genetically attenuated live vaccine to prevent transmission of Toxoplasma gondii by cats

Ramakrishnan, Chandra; Maier, Simone; Walker, Robert A.; Rehrauer, Hubert; Joekel, Deborah E.; Winiger, Rahel R.; Basso, Walter U.; Grigg, Michael E.; Hehl, Adrian B.; Deplazes, Peter; Smith, Nicholas


Almost any warm-blooded creature can be an intermediate host for Toxoplasma gondii. However, sexual reproduction of T. gondii occurs only in felids, wherein fertilisation of haploid macrogametes by haploid microgametes, results in diploid zygotes, around which a protective wall develops, forming unsporulated oocysts. Unsporulated oocysts are shed in the faeces of cats and meiosis gives rise to haploid sporozoites within the oocysts. These, now infectious, sporulated oocysts contaminate...[Show more]

CollectionsANU Research Publications
Date published: 2019-02-06
Type: Journal article
Source: Scientific Reports
DOI: 10.1038/s41598-018-37671-8
Access Rights: Open Access


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