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Roles of Dock8 and hnRNPLL in CD8 T cell survival

Chan, Stephanie Soek-Yeng


CD8 T cells are key players of cell-mediated immunity against intracellular pathogens and must be maintained by homeostatic equilibrium so as to protect the body against recurrent viral infections or tumours. Immunological memory is the crux of an adaptive immune response. A genome-wide immunization screen designed to identify genes involved in long-lived immunity identified two novel genes, Dock8 and Hnrpll, important for long-term memory. This thesis studied the role of DOCK8 and hnRNPLL in...[Show more]

CollectionsRestricted Theses
Date published: 2013
Type: Thesis (PhD)
DOI: 10.25911/5d514b9495b61
Embargoed until: 2021-12-11


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