Roles of Dock8 and hnRNPLL in CD8 T cell survival
CD8 T cells are key players of cell-mediated immunity against intracellular pathogens and must be maintained by homeostatic equilibrium so as to protect the body against recurrent viral infections or tumours. Immunological memory is the crux of an adaptive immune response. A genome-wide immunization screen designed to identify genes involved in long-lived immunity identified two novel genes, Dock8 and Hnrpll, important for long-term memory. This thesis studied the role of DOCK8 and hnRNPLL in...[Show more]
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