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Inflammation-sleep interface in brain disease: TNF, insulin, orexin

Clark, Ian A; Vissel, Bryce


The depth, pattern, timing and duration of unconsciousness, including sleep, vary greatly in inflammatory disease, and are regarded as reliable indicators of disease severity. Similarly, these indicators are applicable to the encephalopathies of sepsis, malaria, and trypanosomiasis, and to viral diseases such as influenza and AIDS. They are also applicable to sterile neuroinflammatory states, including Alzheimer's disease, Parkinson's disease, traumatic brain injury, stroke and type-2 diabetes,...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Journal of Neuroinflammation
DOI: 10.1186/1742-2094-11-51


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