Skip navigation
Skip navigation

Genetic mutations promoting autonomous B cell proliferation

Mapp, Sally Jane


The multi-step nature of neoplastic transformation is relatively well accepted, although the minimum number of genetic perturbations required for the acquisition of a malignant phenotype has not previously been clearly defined. Using retroviral gene transfer, cells harbouring mutated Trp53 in conjunction with overexpressed MYC have been demonstrated to predispose to B cell lymphoma development in mice. We localised retroviral insertion sites in 24 such lymphomas. Many of these integration sites...[Show more]

CollectionsOpen Access Theses
Date published: 2013
Type: Thesis (PhD)
DOI: 10.25911/5d514bae91490


File Description SizeFormat Image
b35683715-Mapp_S.pdf64.77 MBAdobe PDFThumbnail

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator