Genetic mutations promoting autonomous B cell proliferation
The multi-step nature of neoplastic transformation is relatively well accepted, although the minimum number of genetic perturbations required for the acquisition of a malignant phenotype has not previously been clearly defined. Using retroviral gene transfer, cells harbouring mutated Trp53 in conjunction with overexpressed MYC have been demonstrated to predispose to B cell lymphoma development in mice. We localised retroviral insertion sites in 24 such lymphomas. Many of these integration sites...[Show more]
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