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Genetic mutations promoting autonomous B cell proliferation

Mapp, Sally Jane

Description

The multi-step nature of neoplastic transformation is relatively well accepted, although the minimum number of genetic perturbations required for the acquisition of a malignant phenotype has not previously been clearly defined. Using retroviral gene transfer, cells harbouring mutated Trp53 in conjunction with overexpressed MYC have been demonstrated to predispose to B cell lymphoma development in mice. We localised retroviral insertion sites in 24 such lymphomas. Many of these integration sites...[Show more]

CollectionsOpen Access Theses
Date published: 2013
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/156345
DOI: 10.25911/5d514bae91490

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