Evolution of transcriptional inactivation on sex chromosomes in birds and mammals
Differentiated sex chromosomes (XY or ZW) result in a 2:1 gene dosage imbalance between the X or Z and the autosomes, in the heterogametic sex, because genes have been lost from the usually small and heterochromatic sex-specific element (Y or W). This gene loss also results in a 2:1 dosage difference between the sexes for unpartnered genes on the X or Z. Such dosage imbalances may be compensated for by various stratagies in different taxa. In this thesis I examine dosage compensation of the X...[Show more]
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