Transmembrane form of tumor necrosis factor : immunobiology and role in infection and inflammation
Tumor necrosis factor (TNF) is a key cytokine secreted by leukocytes. Although it plays an antimicrobial role in response to infection, many of its effects are detrimental to the host and overproduction is known to lead to pathology. TNF is produced as a transmembrane protein, mTNF, which is proteolytically cleaved to release a secreted form of the protein (sTNF). Of the strategies used by viruses to counter the host, many are directed toward TNF, underscoring the importance of this cytokine...[Show more]
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