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Investigating the complexities of microrna-target interactions in cardiac biology

Hynes, Carly Jane


One in three Australians die of cardiovascular disease and despite advances in treatment it remains the leading cause of death in Australia. MiRNAs play critical roles in the heart and specific miRNAs can promote or prevent cardiac hypertrophy, sparking interest to use miRNAs as therapeutic targets. However, cells can produce both miRNAs and their mRNA targets in multiple processing variants increasing the complexity of miRNA-mediated control. It is therefore critical to elucidate the role of...[Show more]

CollectionsOpen Access Theses
Date published: 2014
Type: Thesis (PhD)
DOI: 10.25911/5d51488596a76


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