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The influence of genetic variation on inducible gene expression

French, Hugh John


Activation of the immune response is dependent on extensive changes in gene expression and it is likely that a major component of inter-individual variation in the immune response is mediated at the level of gene regulation. In this thesis the influence of genetic variation on inducible gene expression is examined in the murine immune response. Primary CD4+ splenocytes were extracted from the inbred mouse strains A/J, C57BL/6J, BALB/c, DBA/2J, and 129x1/SvJ (> 3 animals/strain) and mRNA...[Show more]

CollectionsOpen Access Theses
Date published: 2012
Type: Thesis (PhD)
DOI: 10.25911/5d514af55f9c5


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