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Consequences of myd88 mutations for b cell tolerance

Wang, James Qun


MYD88 mutations, found in 39% of activated B cell type diffuse large B cell lymphoma (ABC-DLBCL) and almost 100% of Waldenstrom macroglobulinemia (WM), have emerged as one of the most frequently recurring mutations in mature B cell malignancies. Strikingly, a single MYD88 L265P mutation predominates in both ABC-DLBCL and WM, and frequently overlaps with mutations in CD79B and TNFAIP3. However, little is known about the consequences of acquiring these mutations for the behaviour of normal mature...[Show more]

CollectionsOpen Access Theses
Date published: 2016
Type: Thesis (PhD)
DOI: 10.25911/5d514f1609f34


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