Japanese encephalitis virus is the leading cause of viral encephalitis in Asia. In spite of this, the immunological correlates for recovery from primary Japanese encephalitis virus (JEV) infection remain poorly defined. In this work, I have first established a mouse model for Japanese encephalitis in which a low-dose virus inoculum was administered subcutaneously into adult C57BL/6 mice. In this model, ~60% of the mice developed fatal encephalitis, concomitant with virus burden in the central...[Show more]
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