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Towards understanding EC coupling protein expression with age

Willemse, Hermia


Sarcopenia is characterised by a decrease in muscle specific force that can only partially be attributed to muscle atrophy. Changes in fiber type composition of muscle have also been observed in humans with age. Additionally, it is suggested that excitation contraction coupling (EC coupling) is impaired in aging by uncoupling of the two calcium channels facilitating EC coupling, the dihydropyridine receptor (DHPR) and the ryanodine receptor (RyR1), perhaps due to a decrease in expression of the...[Show more]

CollectionsOpen Access Theses
Date published: 2014
Type: Thesis (PhD)
DOI: 10.25911/5d51506253ec5


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