Effect of inoculation route on priming pathway and CD8+ T cell immunodominance during Vaccinia virus infection
The CD8+ T cell response is essential for defence of mammals against pathogens and tumours, but its initiation and modulation are not fully understood. This thesis focuses on two aspects of CD8+ T cell responses. First, antigen priming pathways, which dictate the initiation of epitope-specific responses. Second, immunodominance representing the breadth of immune responses. Additionally, we explored the influence of inoculation route on antigen-priming pathways and immunodominance to delineate...[Show more]
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