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Investigation of CD8+ T cell priming by two commonly used Vaccinia virus strains

Wong, Yik Chun


CD8+ T cells help to control virus infections and tumours. Two main pathways, namely direct and cross presentation, are involved in generating and presenting antigenic peptides to induce CD8+ T cell responses. In general, antigens that require minimal processing or are rapidly degraded allow better direct presentation while only stable antigens can be cross presented. Currently, several vaccinia virus (VACV) recombinants are being tested in clinical trials as vaccines to induce protective...[Show more]

CollectionsOpen Access Theses
Date published: 2014
Type: Thesis (PhD)
DOI: 10.25911/5d514c27416df


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