Long-term effects of LPS and high-fat diet on dopaminergic neurodegeneration
Mounting evidence suggests that inflammation is involved in the etiology of neurodegenerative disorders such as Parkinson's disease. It has been reported that the long-term effect of five doses of lipopolysaccharide from Gram-negative bacteria in mice caused activation of microglia and dopaminergic neurodegeneration that was reflected as decreased locomotor activity. In the current study, it is hypothesized that IL-1 beta, a potent proinflammatory cytokine synthesized and released by glia...[Show more]
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