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Long-term effects of LPS and high-fat diet on dopaminergic neurodegeneration

Stojakovic, Andrea


Mounting evidence suggests that inflammation is involved in the etiology of neurodegenerative disorders such as Parkinson's disease. It has been reported that the long-term effect of five doses of lipopolysaccharide from Gram-negative bacteria in mice caused activation of microglia and dopaminergic neurodegeneration that was reflected as decreased locomotor activity. In the current study, it is hypothesized that IL-1 beta, a potent proinflammatory cytokine synthesized and released by glia...[Show more]

CollectionsOpen Access Theses
Date published: 2013
Type: Thesis (PhD)
DOI: 10.25911/5d514c345319c


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