Mechanisms of anthracycline-induced dysfunction of ca2+ handling proteins in the heart
Anthracyclines, such as doxorubicin and daunorubicin, are powerful chemotherapy agents whose use is limited due to the onset of potentially fatal cardiac side effects which include arrhythmogenesis and heart failure. Several proteins important in intracellular Ca2+ signalling have been identified as drug binding targets, including the ryanodine receptor Ca2+ release channel (RyR2), the Ca2+ binding protein calsequestrin (CSQ2) and the Sarco/Endoplasmic Reticulum Ca-ATPase (SERCA2A). The drug...[Show more]
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