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In vitro exploration of interactions between junctin and the Ryanodine receptor from skeletal and cardiac muscle

Li, Linwei

Description

Muscle contraction is dependent on a large Ca2+ release from its intracellular Ca2+ store, the Sarcoplasmic Reticulum (SR), through Ryanodine receptor Ca2+ release channels (RyRs). In the resting state, striated muscle requires a tight control of Ca2+ release through RyRs. Another SR bound protein, junctin, is thought to facilitate this. Located in both skeletal and cardiac muscle, junctin has a short N-terminal domain (Njun) and bulky, highly charged C-terminal domain (Cjun), that are exposed...[Show more]

CollectionsOpen Access Theses
Date published: 2014
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/155890
DOI: 10.25911/5d514e06a7a27

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