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On the function of somatic and dendritic SK channels in cortical pyramidal neurons

Jones, Scott Lewis


Small-conductance Calcium-activated Potassium (SK) channels play an important role in regulating neuronal excitability. Recent evidence indicates SK channels regulate NMDA receptor activation in dendritic spines and play a role in regulating synaptic plasticity. Using confocal fluorescent Calcium imaging, we investigate the activation of SK channels in spines and dendrites of layer 5 (L5) cortical pyramidal neurons during action potentials (APs). The inhibition of SK channels with apamin...[Show more]

CollectionsOpen Access Theses
Date published: 2014
Type: Thesis (PhD)
DOI: 10.25911/5d514e20d070e


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