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Selective glucocorticoid receptor modulation as a therapeutic option in dystrophic muscle

Huynh, Tony

Description

Duchenne Muscular Dystrophy is a devastating neuromuscular condition defined by the absence of the integral sarcolemma-associated protein, dystrophin, and characterised by myofibre necrosis, muscle regeneration, inflammatory infiltration, and premature satellite cell senescence. The anti-inflammatory properties of glucocorticoids, mediated predominantly through monomeric glucocorticoid receptor inhibition of transcription factors such as NF-kappaB (transrepression), are postulated to be an...[Show more]

CollectionsOpen Access Theses
Date published: 2014
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/155870
DOI: 10.25911/5d514e3e23643

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