The role of endothelial connexin40 in the regulation of arterial function and blood pressure
Coordination of cellular activity is essential for cardiovascular functions such as the heart beat and hyperaemia. This is facilitated by gap junctions that connect the cytoplasmic contents of adjacent cells. Human carriers of mutations in the gap junction subunit protein, connexin40 (Cx40), are predisposed to lone atrial fibrillation. However, in addition to the atria of the heart, Cx40 is highly expressed in the vascular endothelium, where it is necessary for the coordination of arterial...[Show more]
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