A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage
Koay, Hui-Fern; Gherardin, Nicholas A; Enders, Anselm; Loh, Liyen; Mackay, Laura K; Almeida, Catarina F; Russ, Brendan E; Nold-Petry, Claudia A; Nold, Marcel F; Bedoui, Sammy; Chen, Zhenjun; Corbett, Alexandra J; Eckle, Sidonia B G; Meehan, Bronwyn; d'Udekem, Yves; Konstantinov, Igor E; Lappas, Martha; Liu, Ligong; Goodnow, Chris C; Fairlie, David P; Rossjohn, Jamie; Chong, Mark M; Kedzierska, Katherine; Berzins, Stuart P; Belz, Gabrielle T; McCluskey, James; Uldrich, Adam P; Godfrey, Dale I; Pellicci, Daniel G
Mucosal-associated invariant T cells (MAIT cells) detect microbial vitamin B2 derivatives presented by the antigen-presenting molecule MR1. Here we defined three developmental stages and checkpoints for the MAIT cell lineage in humans and mice. Stage 1 and stage 2 MAIT cells predominated in thymus, while stage 3 cells progressively increased in abundance extrathymically. Transition through each checkpoint was regulated by MR1, whereas the final checkpoint that generated mature functional MAIT...[Show more]
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