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Most viral peptides displayed by class I MHC on infected cells are immunogenic

Croft, Nathan P; Smith, A. J. Stewart; Pickering, Jana; Sidney, John; Peters, Bjoern; Faridi, Pouya; Witney, Matthew J; Sebastian, Prince; Flesch, Inge E A; Heading, Sally L; Sette, Alessandro; La Gruta, Nicole L; Purcell, Anthony W; Tscharke, David C


CD8+ T cells are essential effectors in antiviral immunity, recognizing short virus-derived peptides presented by MHC class I (pMHCI) on the surface of infected cells. However, the fraction of viral pMHCI on infected cells that are immunogenic has not been shown for any virus. To approach this fundamental question, we used peptide sequencing by high-resolution mass spectrometry to identify more than 170 vaccinia virus pMHCI presented on infected mouse cells. Next, we screened each peptide for...[Show more]

CollectionsANU Research Publications
Date published: 2019-02-04
Type: Journal article
Source: Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.1815239116
Access Rights: Open Access


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